We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |


JAMA. 1927;89(14):1135-1137. doi:10.1001/jama.1927.02690140031009.
Text Size: A A A
Published online


EXPERIMENTAL SORE THROAT PRODUCED WITH SCARLET FEVER STREPTOCOCCI  In 1921, we1 reported the production of experimental sore throat in human volunteers by the inoculation of pure cultures of hemolytic streptococci isolated from early, acute cases of scarlet fever.The inoculations were made by swabbing pure cultures of the hemolytic streptococci over the tonsils and pharynx. In a series of thirty volunteers in which eighteen strains of streptococci were employed, twenty-three remained well after inoculation and seven developed sore throat. In most cases, the first symptoms appeared about forty-eight hours after inoculation. The onset was characterized by sore throat and general malaise, accompanied by a rise in temperature. There was acute swelling of the tonsils and reddening of the mucous membrane over the pharynx and tonsils. A polymorphonuclear leukocytosis was present in all cases. Enlargement of the submaxillary cervical lymph glands occurred in one, and typical follicular tonsillitis in another.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.