Study concept and design: R. Laitio, Parkkola, Saunavaara, Roine, Saraste, Scheinin, Maze, T. Laitio.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: R. Laitio, Arola, Virtanen, Parkkola, Saunavaara, Tiainen, Saraste, Airaksinen, Maze, Vahlberg, T. Laitio.
Critical revision of the manuscript for important intellectual content: R. Laitio, Hynninen, Arola, Parkkola, Saunavaara, Bäcklund, Roine, Grönlund, Ylikoski, Wennervirta, Silvasti, Nukarinen, Tiainen, Saraste, Pietila, Airaksinen, Valanne, Martola, Silvennoinen, Scheinin, Harjola, Niiranen, Korpi, Varpula, Inkinen, Olkkola, Maze, Vahlberg, T. Laitio.
Statistical analysis: Virtanen, Saunavaara, Vahlberg, T. Laitio.
Obtained funding: Roine, T. Laitio.
Administrative, technical, or material support: R. Laitio, Hynninen, Virtanen, Parkkola, Saunavaara, Roine, Grönlund, Ylikoski, Wennervirta, Bäcklund, Silvasti, Nukarinen, Saraste, Airaksinen, Martola, Silvennoinen, Scheinin, Niiranen, Korpi, Varpula, Olkkola, Maze, T. Laitio.
Study supervision: R. Laitio, Hynninen, Parkkola, Saunavaara, Roine, Saraste, Airaksinen, Scheinin, T. Laitio.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr R. Laitio reported receiving travel reimbursement from Octapharma. Dr Saraste reported serving as a consultant to GE and Novartis; receiving funding from Abbott and Actelion for educational lectures; and receiving travel reimbursement from Novartis, Lilly, and Abbott. Dr Airaksinen reported receiving funding from AstraZeneca, Boehringer Ingelheim, Cardiome, and Pfizer for educational lectures. Dr Inkinen reported receiving travel reimbursement from Orion. Dr Maze reported being a founder, board director, and equity shareholder of Neuroprotexeon Company, which intends to commercialize the use of xenon for ongoing acute neurological injury, including its use in successfully resuscitated patients after out-of-hospital cardiac arrest. Dr T. Laitio reported receiving institutional funding from Neuroprotexeon Company. No other disclosures were reported.
Funding/Support: The study was funded by the Academy of Finland and via clinical research funding from the Hospital District of Southwest Finland.
Role of the Funder/Sponsor: The Academy of Finland and the Hospital District of Southwest Finland had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank research nurses Keijo Leivo, RN (Turku University Hospital; who was compensated for his contribution), and Tuukka Tikka, RN (Helsinki University Hospital; who was compensated for his contribution), for taking care of the logistics in this study. We thank Michael E. Moseley, PhD (Stanford University, Stanford, California; who received no compensation), for his invaluable advice and comments during preparation of the manuscript.