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Comment & Response |

Preeclampsia and Congenital Heart Defects—Reply

Nathalie Auger, MD, MSc, FRCPC1; William D. Fraser, MD, MSc, FRCSC2; Laura Arbour, MD, MSc, FRCPC, FCCMG3
[+] Author Affiliations
1Institut national de santé publique du Québec, Montreal, Canada
2Department of Obstetrics and Gynecology, CRCHUS, University of Sherbrooke, Sherbrooke, Canada
3Department of Medical Genetics, University of British Columbia, Vancouver, Canada
JAMA. 2016;315(11):1168-1169. doi:10.1001/jama.2015.19084.
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In Reply Dr Brodwell and colleagues express concern that our analysis included infants born preterm and was possibly biased by heart defects related not to preeclampsia but rather to increased surveillance. The premise is that heart defects are more likely to be misdiagnosed in infants born preterm, as the heart is challenging to visualize or has yet to be fully formed at early gestational ages. Because many women with preeclampsia cannot deliver at term, they posit that the analysis should be restricted to critical heart defects, a group unlikely to be overdiagnosed.

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March 15, 2016
Kristoffer Brodwall, MD; Gottfried Greve, MD, DrMed; Nina Øyen, MD, MPH, DrMed
1Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway
2Department of Clinical Science, University of Bergen, Bergen, Norway
JAMA. 2016;315(11):1167-1168. doi:10.1001/jama.2015.19075.
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