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J. H. Sandground, D.Sc.
JAMA. 1941;117(6):440-441. doi:10.1001/jama.1941.72820320005007c.
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On the score of safety and high efficacy especially against hookworms, tetrachlorethylene (C2Cl4), first introduced into human medicine via the veterinary field by Hall and Shillinger1 in 1925, enjoys great repute as approaching the ideal in anthelmintics. Its sponsors expressed the opinion that tetrachlorethylene would be found to be safer than carbon tetrachloride, a view which has been amply substantiated by later clinical experience. This is also borne out by the pharmacologic studies of Lamson, Robbins and Ward,2 who wrote as follows: "Tetrachlorethylene differs from carbon tetrachloride in being absorbed little, if at all, in the intestinal tract of dogs in the absence of fat. If fat is present, or if enormous doses are given to animals of different species, absorption may take place with symptoms or even death, but these symptoms are those of an overdose of hypnotics, not those of chemical change secondary


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