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JAMA. 1927;89(10):802-803. doi:10.1001/jama.1927.02690100064021.
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Adoption of Calmette's Method of Preventive Inoculation Against Tuberculosis  After many years of work M. Calmette, director of the Pasteur Institute, Paris, and M. Guérin of the Pasteur Institute, Lille, have elaborated a promising method of preventive inoculation. The bacillus of bovine tuberculosis, by artificial cultivation carried on over a period of years, has lost its virulence, although it does not appear to have lost its power of conferring resistance against natural infection. Arrangements have been made by the British with the cooperation of MM. Calmette and Guérin to prepare the vaccine at the veterinary laboratory of the ministry of health. It will be issued for use in suitable herds in which tuberculosis exists, and which, from the prevailing conditions, seem most likely to give a definite answer regarding its efficacy. The idea is to vaccinate within the first fortnight of life all calves born or brought into the herd;


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