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TREATMENT OF PERNICIOUS ANEMIA WITH A HIGH CALORIC DIET, RICH IN VITAMINS

KARL K. KOESSLER, M.D., Ph.D.; SIEGFRIED MAURER, M.D.
JAMA. 1927;89(10):768-774. doi:10.1001/jama.1927.02690100030008.
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In an article a year ago on the relation of anemia, primary and secondary, to vitamin A deficiency, we 1 reported on the experimental production of a blood picture in animals, which in all essential details showed a striking similarity to human pernicious anemia. On the basis of this work we reached the conclusions that:

  1. The fat soluble vitamin A is essential for normal blood regeneration.

  2. The addition of vitamin A to the diet of animals long depleted in their vitamin A reserve brings about rapid formation of new blood cells.

  3. A definite relationship exists between a state of chronic vitamin deficiency and certain anemias in man, and

  4. The routine use of a rationally balanced diet rich in vitamins A, B and C had proved itself of decided value in the blood regeneration of patients suffering from pernicious anemias and is the most promising procedure in the treatment of this

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