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Ancel Keys, Ph.D.; Henry L. Taylor, B.A.; George M. Savage, Ph.D.
JAMA. 1941;117(1):62. doi:10.1001/jama.1941.02820270062024.
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To the Editor:—  The possible utility of solutions of albumin prepared from the blood of domestic animals as a substitute for blood has been mentioned recently by Cohn (Chem. Rev.28:395, 1941). Cohn has not indicated any results of biologic trials and states that study will be needed to see whether such albumins will, in fact, remain in the blood stream and attract or hold water there by virtue of their colloid osmotic pressure. In view of the potential wartime importance of such preparations, we wish to offer some pertinent information on this and other points from studies extending over the past four years in the Laboratory of Physiological Hygiene of the University of Minnesota.We have prepared serum, plasma and plasma albumins and globulins under sterile conditions by precipitation methods with ammonium sulfate, phosphates and alcohols and by extraction methods with alcohols. The donor animals have included the


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