Correction: This article was corrected on May 24, 2016, for a data error.
Study concept and design: Seymour, Iwashyna, Rubenfeld, Kahn, Shankar-Hari, Deutschman, Escobar, Angus.
Acquisition, analysis, or interpretation of data: Liu, Iwashyna, Brunkhorst, Rea, Scherag, Kahn, Singer, Escobar, Angus.
Drafting of the manuscript: Seymour, Singer, Deutschman, Angus.
Critical revision of the manuscript for important intellectual content: Liu, Iwashyna, Brunkhorst, Rea, Scherag, Rubenfeld, Kahn, Shankar-Hari, Singer, Deutschman, Escobar, Angus.
Statistical analysis: Seymour, Liu, Iwashyna, Scherag.
Obtained funding: Escobar.
Administrative, technical, or material support: Brunkhorst, Rea, Scherag, Deutschman, Escobar, Angus.
Study supervision: Deutschman, Escobar.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Seymour reports receipt of personal fees from Beckman Coulter. Dr Singer reports board memberships with InflaRx, Bayer, Biotest, and Merck. Dr Deutschman reports holding patents on materials unrelated to this work and receipt of personal fees from the Centers for Disease Control and Prevention, the World Federation of Societies of Intensive and Critical Care, the Pennsylvania Assembly of Critical Care Medicine, the Society of Critical Care Medicine, the Northern Ireland Society of Critical Care Medicine, the International Sepsis Forum, Stanford University, the Acute Dialysis Quality Initiative, and the European Society of Intensive Care Medicine. Dr Escobar reports receipt of grants from the National Institutes of Health, the Gordon and Betty Moore Foundation, Merck, Sharpe & Dohme, and AstraZeneca-MedImmune. No other disclosures were reported.
Funding/Support: This work was supported in part by the National Institutes of Health (grants K23GM104022 and K23GM112018), the Department of Veterans Affairs (grant HSR&D 11-109), the Permanente Medical Group, and the Center of Sepsis Control and Care, funded by the German Federal Ministry of Education and Research (grant 01 E0 1002/01 E0 1502).
Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: This article does not necessarily represent the view of the US government or Department of Veterans Affairs. Dr Angus, Associate Editor, JAMA, had no role in the evaluation of or decision to publish this article.
Additional Contributions: We acknowledge the European Society of Intensive Care Medicine and Society of Critical Care Medicine for their partial administrative support of this work. We acknowledge the contributions of the 2016 Third International Consensus Sepsis Definitions Task Force members, who were not coauthors, for their review of the manuscript: John C. Marshall, MD, University of Toronto, Toronto, Ontario, Canada; Djilalli Annane, MD, PhD, Critical Care Medicine, School of Medicine, University of Versailles, France; Greg S. Martin, MD, Emory University School of Medicine, Atlanta, Georgia; Michael Bauer, MD, Center for Sepsis Control and Care, University Hospital, Jena, Germany; Steven M. Opal, MD, Infectious Disease Section, Brown University School of Medicine, Providence, Rhode Island; Rinaldo Bellomo, MD, Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, University of Melbourne, and Austin Hospital, Melbourne, Victoria, Australia; Gordon R. Bernard, MD, Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University, Nashville, Tennessee; Jean-Daniel Chiche, MD, PhD, Réanimation Médicale-Hôpital Cochin, Descartes University, Cochin Institute, Paris, France; Craig M. Coopersmith, MD, Emory Critical Care Center, Emory University School of Medicine, Atlanta, Georgia; Tom van der Poll, MD, Academisch Medisch Centrum, Amsterdam, the Netherlands; Richard S. Hotchkiss, MD, Washington University School of Medicine, St Louis, Missouri; Jean-Louis Vincent, MD, PhD, Université Libre de Bruxelles, and Department of Intensive Care, Erasme University Hospital, Brussels, Belgium; and Mitchell M. Levy, MD, Division of Pulmonary and Critical Care Medicine, Brown University School of Medicine, Providence, Rhode Island. These contributions were provided without compensation.