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In This Issue of JAMA |

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JAMA. 2016;315(8):723-725. doi:10.1001/jama.2015.14123.
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Edited by Howard Bauchner, MD, Phil B. Fontanarosa, MD, MBA, and Derek C. Angus, MD, MPH


Seymour and colleagues—members of the Third International Consensus Definitions Task Force (SEPSIS-3) convened to reexamine the definitions of sepsis and septic shock—evaluated the comparative performance of clinical criteria to identify patients with suspected infection at risk of sepsis in a retrospective cohort study involving 148 907 intensive care unit (ICU) patient encounters (primary cohort). The authors assessed the predictive validity for in-hospital mortality using the Sequential [Sepsis-related] Organ Failure Assessment Score (SOFA), the Systemic Inflammatory Response Syndrome (SIRS) criteria, the Logistic Organ Dysfunction System (LODS) score, and a new model termed quick SOFA (qSOFA) in the primary cohort and confirmed their findings in analyses of data from 706 399 additional patient encounters. The authors’ findings support use of SOFA for ICU encounters with suspected infection and qSOFA for suspected infection outside the ICU. In an Editorial, Abraham discusses strengths and limitations of evolving definitions for sepsis and septic shock.

Editorial and Related Articles 1 and 2

Shankar-Hari and colleagues from the Sepsis Definitions Task Force summarize the consensus process undertaken to update the definition of septic shock and to specify clinical criteria that identify adult patients with septic shock. The predictive validity of the criteria were assessed in 3 patient cohorts representing more than 3 million patients. Key clinical criteria for septic shock—defined as a subset of sepsis with both circulatory and metabolic abnormalities associated with a greater risk of mortality than sepsis alone—are the presence of both hypotension requiring vasopressor therapy to maintain mean arterial pressure of 65 mm Hg or greater and serum lactate level greater than 2 mmol/L after adequate fluid resuscitation.

Editorial and Related Articles 1 and 2

In an analysis of prospective data collected during 4 consecutive weeks from 29 144 patients undergoing invasive or noninvasive ventilation in 459 intensive care units in 50 countries, Bellani and colleagues found that 10.4% of patients met diagnostic criteria for acute respiratory distress syndrome (ARDS); however, ARDS appeared to be underrecognized, patterns of care suggested undertreatment, and mortality rates were high. In an Editorial, Clark and Moss discuss the need to improve recognition of ARDS and to ensure patients receive evidence-based care.


Definitions of sepsis and septic shock were last revised in 2001. In light of advances in the understanding of the pathophysiology, management, and epidemiology of sepsis, the Society of Critical Care Medicine and the European Society of Intensive Care Medicine convened a task force to evaluate and update the definitions. Singer and colleagues—members of the Sepsis Definitions Task Force—describe the consensus development process, highlight key findings from the evidence synthesis, and summarize task force recommendations for applying the revised definitions in clinical care.

Editorial and Related Articles 1 and 2

An article in JAMA Surgery reported that when chosen by the family, nonoperative management was an effective treatment strategy for children with uncomplicated acute appendicitis. In this From the JAMA Network article, Telem discusses the efficacy and safety of nonoperative treatment of uncomplicated appendicitis and highlights the need for decision tools to inform patient-physician decision making in the treatment of appendicitis.

This JAMA Clinical Evidence Synopsis by Derry and colleagues summarizes a Cochrane review of 61 randomized trials (8644 total participants) that evaluated topical nonsteroidal anti-inflammatory drugs (NSAIDs) to treat musculoskeletal pain—primarily uncomplicated sprains, strains, and contusions. The review found that compared with placebo, topical NSAIDs were associated with greater pain relief and no increase in adverse events.



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