Recently Cole and his associates1 reported on the results of injections of compounds of bismuth and other heavy metals with the object of enabling patients to recover from the effects of attacks of fever in therapeutic malaria. After a few days rest the attacks were allowed to continue till their number was deemed sufficient for the intended therapeutic effect.
In the Netherlands therapeutic malaria in the treatment of dementia paralytica has been applied since 1921. By the cooperation of the two psychiatric clinics in Amsterdam with the zoologic department of the Institute for Tropical Hygiene I have been enabled to keep in stock the strains of plasmodia necessary for the treatment and to maintain a station for the breeding of mosquitoes, so that the inoculation of patients can be carried out both by mosquito bite and by the injection of infected blood. Furthermore, by this means all the other