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JAMA. 1941;116(16):1776. doi:10.1001/jama.1941.02820160028012.
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FATIGUE  The development of fatigue involves changes in many elements of the neuromuscular apparatus. The role of the central nervous system in muscular fatigue is significant, especially in persons engaged in static work. Simonson and Enzer1 have recently utilized the fusion frequency technic for the quantitative measurement of fatigue of the nervous system. Subjects are placed before a light, in front of which is a rotating shutter giving rise to flickers of light. The fusion frequency of flicker is stated to be the rate of the light flashes which is just necessary to give to the subject the effect of continuous illumination. Nineteen subjects were tested fifty-three times for their fusion frequency at the beginning and end of the day's work. At the end of the day the ability to discriminate flicker was lessened. While the number of experiments was relatively small, the results were uniform. Such factors as

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