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Ushering Hypertension Into a New Era of Precision Medicine

Theodore A. Kotchen, MD1; Allen W. Cowley Jr, PhD2; Mingyu Liang, MB, PhD2
[+] Author Affiliations
1Department of Medicine, Medical College of Wisconsin, Milwaukee
2Center of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee
JAMA. 2016;315(4):343-344. doi:10.1001/jama.2015.18359.
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This Viewpoint discusses the potential influence of precision medicine that incorporates epigenetic analysis in effectively treating hypertension.

Approximately 80 million US adults have hypertension, and hypertension remains a leading risk factor for stroke and cardiovascular disease.1 In 2009-2010, 48% of treated hypertensive patients in the United States were taking more than 1 drug, and blood pressure remained uncontrolled among 40% of those receiving drug treatment.1 Current guidelines for prevention and treatment of hypertension are based on observational studies in populations and clinical trials in large groups of patients. Precision medicine and epigenetics are 2 emerging and complementary strategies that have the potential to alter clinical approaches to understanding and treating hypertension. Both approaches have the goal of more effective hypertension control by providing personalized targets for preventive and therapeutic interventions.

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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