It is indeed an honor to have been invited by Dr. Cowdry and the Board of the Barnard Free Skin and Cancer Hospital to give the second Barnard Hospital Lecture, particularly because St. Louis is one of the oldest and most important centers of experimental and clinical cancer research in the country.
Since I am a laboratory worker, it was with some misgiving that I agreed to speak to you on the possibilities of improved therapy for cancer patients. However, I shall deal mainly with fundamental principles of therapy, and these are essentially the same, whether they arise in the clinic or in the experimental laboratory. It is my aim to discuss, briefly and as objectively as possible, various points which to my mind may lead to improvements in cancer therapy. These may be grouped into two broad classes: first, the more widespread application of known methods and their improvements;