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Comment & Response |

Electronic Health Records as Sources of Research Data—Reply

Derek C. Angus, MD, MPH1
[+] Author Affiliations
1Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and Associate Editor, JAMA
JAMA. 2016;315(2):202. doi:10.1001/jama.2015.15422.
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In Reply I agree with Dr Opmeer that an important barrier to the conduct of high-quality RCTs nested in the EHR will be the quality of the EHR itself. I specifically noted in the Viewpoint that this would arguably be the greatest challenge.

Opmeer focuses on lack of completeness, validity, and reliability of clinical data in the EHR. Even though I share his concerns, I would point out that these same threats already compromise all clinical research.


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January 12, 2016
Brent C. Opmeer, PhD
1Clinical Research Unit, Academic Medical Center, Amsterdam, the Netherlands
JAMA. 2016;315(2):201-202. doi:10.1001/jama.2015.15419.
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