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JAMA. 1934;102(7):543. doi:10.1001/jama.1934.02750070041016.
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POTENT BACTERIA-FREE VACCINE VIRUS GROWN ON CHICK EMBRYO MEMBRANES  Goodpasture and his co-workers1 in the Vanderbilt University Medical School have shown that vaccine virus can be grown on the chorio-allantoic membrane of the chick embryo. These results have been confirmed with dermal strains of vaccine.2 It now appears that this method can be used for the production of vaccine virus on a large scale.3 At present, vaccine virus is obtained from calves artificially inoculated on the skin of the abdomen, where the lesions of vaccinia or cowpox develop. The main objection to the calf virus is that it is not free from bacteria and other contaminants. In order to obtain absolutely pure virus, Goodpasture and Buddingh ground up embryo chick membranes, on which the virus was growing after inoculation with a dermal strain, and filtered the suspension through the Berkefeld N filter. The bacteria-free filtrate was centrifugated


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