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IMMUNITY VS. ANTIBODY TITER IN POLIOMYELITIS

JAMA. 1941;116(11):1146. doi:10.1001/jama.1941.02820110110013.
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Detailed studies of immunity in monkeys convalescent from poliomyelitis are reported by Kessel and Stimpert1 of the University of Southern California School of Medicine. Their data seem to furnish the first statistically adequate evidence of the lack of correlation between tissue immunity and antibody titer in this disease.

Occasional discrepancy between serum titer and susceptibility to poliomyelitis has been suggested by numerous investigators. Schultz, Gebhardt and Bullock,2 for example, found that specific complement fixing and precipitating antibodies are often absent from the serum of hyperimmunized convalescent monkeys. This was confirmed by Sabin and Olitsky,3 who found that experimentally infected monkeys often develop a resistance to intranasally instilled homologous virus before virucidal antibodies can be detected in their blood stream. In contrast, Olitsky and Cox4 found that virucidal antibodies are often produced as a result of the injection of chemically killed viruses, without the production of demonstrable

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