Several types of cholesterol occur in the bloodstream, the most important of which are low-density lipoprotein (“bad”) cholesterol (LDL-C) and high-density lipoprotein (“good”) cholesterol (HDL-C). Having high cholesterol generally refers to having high LDL-C levels. Having high LDL-C increases the risk of having plaque buildup inside blood vessels, a condition called atherosclerosis. When atherosclerosis occurs in the blood vessels of the heart or brain, it can lead to heart attacks and strokes, 2 forms of cardiovascular disease. Cardiovascular disease is currently the leading cause of death in the United States.