Group Information: T1D Exchange Clinic Network Metformin RCT Study Group members are listed in Supplement 2.
Study concept and design: Libman, Miller, Haller, Raman, Tamborlane, Saenz, Beck, Nadeau.
Acquisition, analysis, or interpretation of data: Libman, Miller, DiMeglio, Bethin, Katz, Shah, Simmons, Haller, Raman, Tamborlane, Coffey, Nadeau.
Drafting of the manuscript: Libman, Miller, DiMeglio, Shah, Saenz, Nadeau.
Critical revision of the manuscript for important intellectual content: Libman, Miller, DiMeglio, Bethin, Katz, Simmons, Haller, Raman, Tamborlane, Coffey, Beck, Nadeau.
Statistical analysis: Libman, Miller, DiMeglio.
Obtained funding: Miller, Saenz, Nadeau.
Administrative, technical, or material support: Miller, Bethin, Shah, Haller, Tamborlane, Coffey, Saenz, Beck.
Study supervision: Miller, DiMeglio, Bethin, Shah, Haller, Tamborlane, Saenz, Nadeau.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Libman reports receipt of a grant from JDRF and of grants to the institution from Novo Nordisk. Dr DiMeglio reports receipt of grants to the institution from Novo Nordisk and Medtronic. Dr Simmons reports receipt of a grant from the Helmsley Foundation. Dr Raman reports receipt of remuneration for participation on the protocol steering committee from JAEB Center for Health Research, and a grant from the Jucenile Diabetes Research Foundation. Dr Tamborlane reports receipt of consultancy fees from Novo Nordisk. Dr Beck reports receipt of a grant to the institution from JRDF. No other disclosures were reported.
Funding/Support: Funding was provided by the Juvenile Diabetes Research Foundation. Part of Dr Katz’s time was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (K12DK094721).
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.