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THE HORMONE OF THE ADRENAL CORTEX

JAMA. 1931;96(4):273-274. doi:10.1001/jama.1931.02720300043015.
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The progress made in the more recent study of adrenal functions after many years in which an impasse seemed to have been reached is alike gratifying to the scientific investigator and promising to the puzzled clinician. No one doubted that the adrenal structures play an important and even an indispensable part in life; and the pathologist has helped to fix responsibility for human disaster on disease of these organs. So long as attention was fixed almost exclusively on the medulla of the adrenal, because of its relationship to the well defined potent hormone epinephrine, the remaining functions of the cortex were left obscure. When once the cortical parts of the gland were given more intensive consideration, their essential rôle was promptly discovered. The biochemists thereupon demonstrated that the cortex, too, could be made to yield a uniquely potent component—a hormone truly essential to life and capable of passing the test

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