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Comment & Response |

Notice of Retraction: Ahimastos AA, et al. Effect of Perindopril on Large Artery Stiffness and Aortic Root Diameter in Patients With Marfan Syndrome: A Randomized Controlled Trial. JAMA. 2007;298(13):1539-1547. FREE

Bronwyn A. Kingwell, PhD1; Anuradha Aggarwal, FRACP, PhD2; Kellie M. D’Orsa, DMU; Melissa F. Formosa, BSc1; Anthony J. White, FRACP, PhD3; Ravi Savarirayan, FRACP, MD4; Anthony M. Dart, DPhil, FRCP1
[+] Author Affiliations
1Baker IDI Heart and Diabetes Institute, Melbourne, Australia
2Royal Melbourne Hospital, Melbourne, Australia
3Monash Heart, Clayton, Australia
4Murdoch Childrens Research Institute and University of Melbourne, Melbourne, Australia
JAMA. 2015;314(24):2692-2693. doi:10.1001/jama.2015.16678.
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Published online

To the Editor We wish to retract the article “Effect of Perindopril on Large Artery Stiffness and Aortic Root Diameter in Patients With Marfan Syndrome: A Randomized Controlled Trial,” published in the October 3, 2007, issue of JAMA,1 based on inadequate validation of primary data sources and data misrepresentation. An independent review was conducted by the Baker IDI Heart and Diabetes Institute following an admission of scientific misconduct by the first author (Anna A. Ahimastos, PhD) in relation to the data included in another study2 that has since been retracted.3 This review resulted in our decision to retract this additional article.1 We do not believe that management guidelines for Marfan syndrome have been changed as a result of this small clinical trial.

While clinical governance procedures have been strengthened since publication of this study, the Institute has commenced a review with the purpose to further strengthen current audit practices and to minimize any possible risk of recurrence of such behavior. We were not found to be involved in any research misconduct, but we do acknowledge the responsibility for our authorship of this article and for supervising the overall study and sincerely apologize to the editors, reviewers, and readers of JAMA. We are committed to correcting the public record, notifying relevant stakeholders, and implementing practices to prevent recurrence.

ARTICLE INFORMATION

Section Editor: Jody W. Zylke, MD, Deputy Editor.

Corresponding Author: Bronwyn A. Kingwell, PhD, Baker IDI Heart and Diabetes Institute, 75 Commercial Rd, Melbourne VIC 3004, Australia (bronwyn.kingwell@bakeridi.edu.au).

Published Online: November 23, 2015. doi:10.1001/jama.2015.16678.

REFERENCES

Ahimastos  AA, Aggarwal  A, D’Orsa  KM,  et al.  Effect of perindopril on large artery stiffness and aortic root diameter in patients with Marfan syndrome: a randomized controlled trial. JAMA. 2007;298(13):1539-1547.
PubMed   |  Link to Article
Ahimastos  AA, Walker  PJ, Askew  C,  et al.  Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial. JAMA. 2013;309(5):453-460.
PubMed   |  Link to Article
Ahimastos  AA, Askew  C, Leicht  A,  et al.  Notice of retraction: Ahimastos AA, et al. Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial. JAMA. 2013;309(5):453-460. JAMA. 2015;314(14):1520-1521.
PubMed   |  Link to Article

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References

Ahimastos  AA, Aggarwal  A, D’Orsa  KM,  et al.  Effect of perindopril on large artery stiffness and aortic root diameter in patients with Marfan syndrome: a randomized controlled trial. JAMA. 2007;298(13):1539-1547.
PubMed   |  Link to Article
Ahimastos  AA, Walker  PJ, Askew  C,  et al.  Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial. JAMA. 2013;309(5):453-460.
PubMed   |  Link to Article
Ahimastos  AA, Askew  C, Leicht  A,  et al.  Notice of retraction: Ahimastos AA, et al. Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial. JAMA. 2013;309(5):453-460. JAMA. 2015;314(14):1520-1521.
PubMed   |  Link to Article
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