I have had the opportunity to study a family in which ten cases of diabetes have occurred in two generations.
The first generation consisted of twenty-eight persons, the children of Mr. A, and of his two sisters, Mrs. B and Mrs. C. Five were children of Mr. A; eleven, of Mrs. B; twelve of Mrs. C. Three persons were lost trace of more than thirty-five years ago. Of the remaining twenty-five, eight developed diabetes, while seventeen did not develop diabetes; eleven are now living, fourteen have died. Of the eleven living, four have diabetes and seven are free from the disease. Of the fourteen dead, four died of diabetes, while ten died from other causes, four in infancy. In this generation there have been five amputations of a leg for diabetic gangrene; three of the patients who underwent amputation are living, two have died of diabetes. Information is lacking for