Correction: This article was corrected online on December 14, 2015, for typographical errors in a table and on March 1, 2016, for an omission in the supplementary material.
Published Online: November 13, 2015. doi:10.1001/jama.2015.15217.
Study concept and design: Gross, Glassman, Jampol, Aiello, Baker, Bressler, Elman, Ferris, Marcus, Melia, Stockdale, Sun, Beck.
Acquisition, analysis, or interpretation of data: Gross, Glassman, Jampol, Inusah, Aiello, Antoszyk, Baker, Berger, Bressler, Browning, Elman, Ferris, Friedman, Marcus, Melia, Sun.
Drafting of the manuscript: Gross, Glassman, Jampol, Inusah, Bressler, Marcus.
Critical revision of the manuscript for important intellectual content: Gross, Jampol, Aiello, Antoszyk, Baker, Berger, Bressler, Browning, Elman, Ferris, Friedman, Marcus, Melia, Stockdale, Sun, Beck.
Statistical analysis: Glassman, Inusah, Melia, Beck.
Obtained funding: Glassman, Jampol, Bressler.
Administrative, technical, or material support: Gross, Glassman, Jampol, Berger, Bressler, Elman, Friedman, Stockdale, Beck.
Study supervision: Gross, Glassman, Jampol, Aiello, Baker, Bressler, Browning, Elman, Ferris, Melia, Sun, Beck.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Gross reports grants and personal fees from Jaeb Center for Health Research, drug samples for office use from Genentech, and grants from Regeneron. Mr Glassman reports grants to his institution from Genentech/Roche and Regeneron. Dr Aiello reports personal fees for consultancy from Thrombogenics, Kalvista, Sanovas, Eisai, Merck, and Lilly. Dr Antoszyk reports honoraria/consulting fees from Alimera Sciences, Novartis, and Iconic Therapeutics and vice chairmanship for Jaeb Center for Health Research. Dr Berger reports research support from Genentech. Dr Bressler reports grants from Northwestern University and grants to his institution from Bayer, Lumenis, the National Institutes of Health, and Novartis. Dr Browning reports grants from Novartis, Regeneron, Genentech, Aerpio, Alcon, and Allergan, personal fees for consultancy from Alimera, book royalties from Springer, and stock in Zeiss. Dr Marcus reports clinical research grants and/or personal fees for consultancy from Genentech, Roche, Regeneron, Thrombogenics, Alimera, Acucela, Lpath, Alcon, Allergan, GlaxoSmithKline, Pfizer, Ophthotech, and Allegro. Ms Melia reports data and safety monitoring board membership for Alimera. Dr Sun reports grants from Genentech, nonfinancial support from Optovue and Boston Micromachines, research support from Kalvista, and personal fees from Novartis, Regeneron, Eisai, Kowa, Allergan, Bayer, and Abbott. No other disclosures were reported. A complete list of all DRCR.net investigator financial disclosures can be found at http://www.drcr.net.
Funding/Support: This study was supported through a cooperative agreement from the National Eye Institute and the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services (grants EY14231, EY23207, and EY18817). Genentech provided ranibizumab for the study and funds to the DRCR.net to defray the study’s clinical site costs.
Role of the Funders/Sponsors: The National Institutes of Health participated in oversight of the conduct of the study and review of the manuscript but not directly in the design or conduct of the study nor in the collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication. Per the DRCR.net Industry Collaboration Guidelines (available at http://www.drcr.net), the DRCR.net had complete control over the design of the protocol, ownership of the data, and all editorial content of presentations and publications related to the protocol.
Disclaimer: Dr Bressler, Editor of JAMA Opthalmology, had no role in the decision to publish this article.