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R. Sterling Mueller, M.D.
JAMA. 1941;116(4):329. doi:10.1001/jama.1941.02820040063023.
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To the Editor:—  In the Nov. 16, 1940 issue of The Journal, the local use of sulfanilamide is discussed in an editorial. Reference was made of its use in solution as a direct irrigation of the wound in cases of combined abdominoperineal or posterior resection of the rectum. During the past year at the Roosevelt Hospital we have been using the powdered crystalline sulfanilamide directly in the peritoneal cavity at the time of operation.On Jan. 10, 1940 I used the crystalline drug locally in the peritoneal cavity in a critical case of diffuse peritonitis due to a ruptured appendix. Shortly after the recovery of this patient, its local peritoneal use became routine at Roosevelt Hospital in cases of abdominal infection and it was used also prophylactically in certain types of intestinal resection. To date 175 patients have been treated in this manner with excellent results. Of the 175 cases


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