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George B. Craddock, M.D.; Russell V. Bowers, M.Sc.
JAMA. 1941;116(4):296-298. doi:10.1001/jama.1941.62820040002010a.
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In 1938 Whitby1 demonstrated the effectiveness of sulfapyridine against pneumococcic infections in mice. A number of favorable reports2 have appeared which indicate that this drug has pronounced therapeutic value in the treatment of pneumococcic meningitis. During the past months Hodes and his associates3 have used sulfapyridine and its sodium salt in 17 cases, with 47 per cent recovery. Recently Kolmer4 presented a comprehensive review of sulfapyridine therapy in pneumococcic meningitis and discussed its therapeutic value.

We are presenting a patient with recurrent pneumococcic meningitis who was treated with sulfapyridine in each episode. The sulfapyridine concentrations of the blood and spinal fluid were of peculiar significance.


First Admission.—  L. R., a Negro woman aged 32, was admitted to St. Philip Hospital (Negro division of the Medical College of Virginia hospitals) Dec. 15, 1939 and discharged apparently well December 31. Her history revealed that


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