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JAMA. 1941;116(4):280-281. doi:10.1001/jama.1941.02820040014005.
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With the introduction of methods for the estimation of sulfonamide compounds in blood and tissue, it was soon found that these compounds passed readily into most body tissue and fluids.1 Observations have been made on saliva, milk, pleural fluid, spinal fluid, skin and sweat, bile, pancreatic juice, synovial fluid, placental blood and urine. With the exception of urine and spinal fluid, observations have not been extensive and there is still considerable information lacking concerning the distribution pattern of the various sulfonamide compounds in the body.

Long and Bliss2 state that in the case of sulfanilamide the level in most body fluids is from 10 to 25 per cent lower than in the blood. Sulfanilamide is apparently more diffusible than sulfapyridine or sulfathiazole.

Long and Finestone3 observed that sulfapyridine passed over into the spinal fluid in from one half to three fourths of the concentration which exists in


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