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January 25, 1941, Vol 116, No. 4 >
ARTICLE | January 25, 1941

SULFANILAMIDE IN THE THERAPY OF ACTINOMYCOSIS

LEONARD DOBSON, M.D.; EMILE HOLMAN, M.D.; WINDSOR CUTTING, M.D.
JAMA. 1941;116(4):272-275. doi:10.1001/jama.1941.02820040006003.
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Chemotherapeutic successes in the field of bacterial and protozoal infections have not yet been equaled in the virus or fungus groups. Of the virus infections, only venereal lymphogranuloma and trachoma have seemed responsive to sulfanilamide. There have been relatively few reports of the effect of sulfanilamide in fungous infections.

Six clinical reports have mentioned the use of sulfanilamide or related compounds in actinomycosis, and one report describes a trial of the drug in an experimental infection. The earliest of these was that of Walker,1 who in 1938 reported a case of abdominal actinomycosis arising from the appendix, which healed quickly after two courses of sulfanilamide. The first course lasted six days and the second five days, with an interval of ten days. The dosage was 1 Gm. three times a day throughout. Compound solution of iodine and potassium iodide had been given previously without effect.

Bailey,2 also in

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