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January 17, 1931, Vol 96, No. 3 >

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ARTICLE | January 17, 1931

OBSERVATIONS ON THE TREATMENT OF SYPHILIS OF THE LIVER

PAUL A. O'LEARY, M.D.
JAMA. 1931;96(3):183-187. doi:10.1001/jama.1931.02720290027007.
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Experimental study1 of cirrhosis of the liver has demonstrated that, if 10 per cent of the hepatic tissue is functioning normally, the normal quantity and quality of bile may be excreted, the normal blood sugar curve may be maintained, the deaminization of amino-acids will occur, and the formation of urea and destruction of uric acid will take place. It was likewise demonstrated in the laboratory animal that the hepatic cell has a regenerative ability of 100 per cent, a function which may be prevented if the portal blood is diverted or if obstructive jaundice or extensive toxic cirrhosis is present. The major portion of the organ must be functionless long before symptoms of dysfunction appear.

These data are significant in a study of syphilis of the liver because of the fact that syphilis can produce in the liver a variety of syndromes clinically comparable to most of the other

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