Study concept and design: Sartipy, Holzmann, Edgren.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Sartipy, Holzmann, Edgren.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Hjalgrim, Edgren.
Obtained funding: All authors.
Administrative, technical, or material support: Sartipy, Holzmann, Edgren.
Study supervision: Hjalgrim.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Sartipy reported serving on a scientific advisory board and as a consultant for Bayer.
Funding/Support: Funding was provided by grants from the Swedish Medical Society (SLS-330221 awarded to Dr Sartipy), Karolinska Institutet Foundations and Funds (40842 awarded to Dr Sartipy), and the Mats Kleberg Foundation (2014-00017 awarded to Dr Sartipy). The SCANDAT2 database assembly was financed by Swedish Research Council (2011-30405, 2007-7469), the Swedish Heart-Lung Foundation (20090710), and the Swedish Society for Medical Research (Dr Edgren).
Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We are indebted to all the blood banks in Sweden for collecting and contributing data to this study. We also thank the SWEDEHEART steering committee for providing the data.
Trial Registration: clinicaltrials.gov Identifier: NCT02276950