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CLINICAL DETERMINATION OF THE ALBUMIN GLOBULIN RATIO IN SPINAL FLUID

WILLIAM G. EXTON, M.D.; ANTON R. ROSE, Ph.D.
JAMA. 1931;96(1):36-38. doi:10.1001/jama.1931.02720270038011.
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One of the unexpected results of the publications of our urinary protein methods1 was the receipt of many communications from workers interested in applying them to spinal fluids. As the methods are just as applicable to blood and spinal fluid as they are to urine, their successful application to the determination of the total protein of these materials followed as a matter of course. Following the publication of articles on the scopometer2 and the protein fractionation methods,3 our correspondents impressed on us the need of a practicable clinical method for determining the albumin and globulin in spinal fluids and of obtaining from them the albumin globulin ratios.

The Prudential Laboratory tries to discourage its patrons from sending spinal fluids to it because of the danger of loss in the mails. It was therefore necessary to accept offers to supply material for the experimental work involved in modifying

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