The author has collected in this interesting volume the various factors that have to do with the permeability of the blood vessels and tissues. The book is divided into three parts. The first part is concerned with the permeability of the capillary endothelium to various soluble and insoluble substances and dyestuffs under different conditions, followed by an account of the penetration and localization of the common bacteria and viruses. The second part deals with the relation of such permeability and localization to various disease processes and inflammations. The third part discusses the practical importance of the factors described and their importance in the understanding of infections and tumor metastases. Valuable therapeutic suggestions are given.