Published Online: October 5, 2015. doi:10.1001/jama.2015.12160.
Study concept and design: Grijalva, Williams, Ampofo, Pavia, Stockmann, McCullers, Arnold, Anderson, Finelli, Jain, Edwards.
Acquisition, analysis, or interpretation of data: Grijalva, Zhu, Williams, Self, Pavia, Stockmann, Arnold, Wunderink, Anderson, Lindstrom, Fry, Foppa, Finelli, Bramley, Jain, Griffin, Edwards.
Drafting of the manuscript: Grijalva, Ampofo, Stockmann, Anderson, Finelli, Jain.
Critical revision of the manuscript for important intellectual content: Grijalva, Zhu, Williams, Self, Pavia, Stockmann, McCullers, Arnold, Wunderink, Anderson, Lindstrom, Fry, Foppa, Finelli, Bramley, Jain, Griffin, Edwards.
Statistical analysis: Grijalva, Zhu, Williams, Stockmann, Finelli.
Obtained funding: Grijalva, Williams, Wunderink, Jain, Edwards.
Administrative, technical, or material support: Williams, Self, Ampofo, Stockmann, Wunderink, Lindstrom, Foppa, Bramley, Jain, Edwards.
Study supervision: Grijalva, Self, Stockmann, Finelli, Jain, Edwards.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Grijalva reported having served as a consultant with Pfizer. Dr Self reported having received grants from bioMerieux, Affinium Pharmaceuticals, Astute Medical, Crucell Holland, BRAHMS, Pfizer, Rapid Pathogen Screening, Venaxis, and Cempra Pharmaceuticals and other support from CareFusion and BioFire Diagnostics and having a patent pending 13/632,874 (Sterile Blood Culture Collection System). Dr Ampofo reported having received grants from the National Institutes of Health and other support from GlaxoSmithKline and Cubist Pharmaceuticals and having collaborated with BioFire Diagnostics. Dr Pavia reported having received grants from Pfizer and the Agency for Healthcare Research and Quality and other support from BioFire Diagnostics, Medscape, and Antimicrobial Therapy. Dr Stockmann reported having received grants from the American Foundation for Pharmaceutical Education. Dr Arnold reported having received grants from GlaxoSmithKline. Dr Wunderink reported having participated on a data and safety monitoring committee for Vertex and having received other support from Visterra, bioMerieux, and Roche. Dr Anderson reported having received grants and other support from MedImmune, Roche, and AbbVie. Dr Griffin reported having received grants from MedImmune. Dr Edwards reported having received grants from the National Institutes of Health and Novartis and having participated on data monitoring boards for the University of Maryland and Novartis. No other disclosures were reported.
Funding/Support: This study was funded by the Influenza Division in the National Center for Immunization and Respiratory Diseases at the Centers for Disease Control and Prevention (CDC).
Role of the Funders/Sponsors: Investigators from CDC, the study sponsor, participated in the conduct of the study; collection, management, and interpretation of the data; preparation, review, and approval of the manuscript. The sponsors did not perform any of the study analyses.
Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention or the Department of Veterans Affairs.
Previous Presentation: An abstract of part of this work was presented at the IDWeek Annual meeting; October 2-6, 2013; San Francisco, California.