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Comment & Response |

Treatment of Uncomplicated Acute Appendicitis—Reply

Paulina Salminen, MD, PhD1; Juha M. Grönroos, MD, PhD1
[+] Author Affiliations
1Department of Acute and Digestive Surgery, Turku University Hospital, Turku, Finland
JAMA. 2015;314(13):1403-1404. doi:10.1001/jama.2015.11441.
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In Reply The APPAC trial tested the hypothesis that uncomplicated acute appendicitis can be successfully treated with antibiotics by comparing antibiotic therapy with emergency open appendectomy. There is an intrinsic difficulty in defining a common primary outcome for these dissimilar treatments. Although Drs Minneci and Deans advocate for more patient-centric outcomes, we aimed to identify a clear and concise definition of efficacy (ie, resolution of acute appendicitis) that would apply to both treatments.


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October 6, 2015
Gabriele Pollara, MBBS, MRCP, FRCPath; Michael Marks, MB BS, MSc, MRCP
1Division of Infection and Immunity, University College London, London, England
2Clinical Research Department, London School of Hygiene and Tropical Medicine, London, England
JAMA. 2015;314(13):1402. doi:10.1001/jama.2015.11420.
October 6, 2015
Maryam Alfa-Wali, PhD; Paul Toomey, FRCS; Ash Gupta, FRCS
1Epsom and St Helier University NHS Trust, Surrey, England
JAMA. 2015;314(13):1402-1403. doi:10.1001/jama.2015.11423.
October 6, 2015
Peter C. Minneci, MD, MHSc; Katherine J. Deans, MD, MHSc
1Center for Surgical Outcomes Research, Nationwide Children’s Hospital, Columbus, Ohio
JAMA. 2015;314(13):1401-1402. doi:10.1001/jama.2015.11426.
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