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Comment & Response |

Treatment of Uncomplicated Acute Appendicitis

Peter C. Minneci, MD, MHSc1; Katherine J. Deans, MD, MHSc1
[+] Author Affiliations
1Center for Surgical Outcomes Research, Nationwide Children’s Hospital, Columbus, Ohio
JAMA. 2015;314(13):1401-1402. doi:10.1001/jama.2015.11426.
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To the Editor The use of a noninferiority design in the Appendicitis Acuta (APPAC) trial allowed for the assessment of primary outcomes specific to each treatment.1 However, we believe that the chosen outcomes were not equally patient-centric, leading to the erroneous conclusion that antibiotics did not meet the prespecified criterion for noninferiority compared with appendectomy.1


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October 6, 2015
Paulina Salminen, MD, PhD; Juha M. Grönroos, MD, PhD
1Department of Acute and Digestive Surgery, Turku University Hospital, Turku, Finland
JAMA. 2015;314(13):1403-1404. doi:10.1001/jama.2015.11441.
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