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EXPERIMENTAL INVESTIGATIONS ON CONVULSIONS:  THEIR BEARING ON EPILEPSY

WALTER E. DANDY, M.D.
JAMA. 1927;88(2):90-91. doi:10.1001/jama.1927.02680280020005.
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In a recent publication 1 it was shown that when the motor cortex of dogs or cats was injured by incision or inclusion of a foreign body, spontaneous convulsions appeared from time to time thereafter, and that subsequently over a period of at least many weeks and months convulsions could be induced by wormwood oil (absinthe) with from one third to one seventh of the dose required to produce convulsions in the normal animal. In these experiments (all unilateral) we were careful not to destroy completely, but rather only to injure the motor cortex, hoping thereby to parallel as closely as possible the conditions that seemed to obtain in human epilepsy. Our conclusions from these experiments were that (1) the motor cortex, once injured, thereafter lowers the threshold at which convulsions appear, and (2) injuries to other parts of the brain did not produce results so striking, but suggest a

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