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STEPS TOWARD DRUG THERAPY IN DIABETES

JAMA. 1927;88(1):34-35. doi:10.1001/jama.1927.02680270034012.
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In the history of our knowledge of diabetes the name of Minkowski, now director of the medical clinic of the University of Breslau, is eminent. The foundation stone of most of the advances made in the study of diabetes in the last four decades is the classic observation of von Mering and Minkowski, in 1889, that complete removal of the pancreas from animals leads to the appearance of a severe diabetes. From this fundamental fact, Minkowski long ago drew the conclusion that the pancreas must secrete something besides the pancreatic juice, which unknown substance is necessary to prevent diabetes. This conclusion waited more than thirty years for its final proof through the production of insulin by Banting, Best and Collip, although numerous other experimenters had foreshadowed this demonstration by obtaining pancreatic preparations with greater or less effect on carbohydrate metabolism. Now comes a new addition to the story of diabetes

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