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C. F. Charlton, M.D.
JAMA. 1926;87(23):1934. doi:10.1001/jama.1926.02680230058028.
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To the Editor:  —In The Journal, November 6, Dr. A. U. Desjardins reaffirms his well known position on the effect of radium and roentgen rays. This discourse is reactionary against the general belief in a physiologic response to irradiation (Editorial, Am. J. Roentgenol., August, 1924).Ewing stated the case clearly in the Caldwell Lecture of 1925 when he said that if direct action had been depended on, radiation therapy would have come to an end years ago when Francis Carter Wood showed that it required seven times the erythema dose to kill certain mouse cancers in vitro.Again, Murphy of the Rockefeller Institute inadvertently experienced the same result. This led him to investigate the subject extensively. He exposed a cancer culture to massive doses of roentgen ray every five weeks for a year and a half, then to find only a transitory interference with growth when it was grafted. On


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