0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

CAUSE OF THE DELAYED CLOTTING IN HEMOPHILIA

JAMA. 1926;87(23):1918-1919. doi:10.1001/jama.1926.02680230042014.
Text Size: A A A
Published online

Among the various pathologic conditions in which an augmented tendency to hemorrhage is apparent, the special disorder known as hemophilia has certain unique features. Its hereditary character is conspicuous; indeed, as Wells 1 has remarked, since hemophilia seems, superficially at least, to depend on some alteration in a chemical property of the blood, namely, coagulability, it is frequently regarded as an example of hereditary transmission of chemical abnormality. Characteristic, uniformly present structural anomalies have not been discovered in hemophilic persons, so that etiologic explanations must be sought elsewhere. The incidence of hemophilia exhibits some analogy to the occurrence of chemical abnormalities of metabolism, such as cystinuria, alkaptonuria and pentosuria, so far as the hereditary features are concerned. It has been termed "the most hereditary of all hereditary diseases."

It is obviously of no small importance to discover the factors responsible for the condition of the blood in hemophilia. The bleedings,

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

* * SCHEDULED MAINTENANCE * *

Our websites may be periodically unavailable between midnight and 04:00 ET Thursday, July 10th, for regularly scheduled maintenance.

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();