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Comment & Response |

Amyloid Pathology, Cognitive Impairment, and Alzheimer Disease Risk

Michael Wagner, PhD1; Frank Jessen, MD2
[+] Author Affiliations
1Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
2Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
JAMA. 2015;314(11):1177. doi:10.1001/jama.2015.9716.
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To the Editor In a recent meta-analysis, Ms Jansen and colleagues1 stated that “the presence of SCI [subjective cognitive impairment] in a memory clinic population might not be associated with an increased risk for AD [Alzheimer disease].”

This conclusion cannot be drawn from the cross-sectional design of the included studies. It also contradicts a recent meta-analysis of longitudinal studies,2 which identified an increased dementia risk among patients with SCI.


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September 15, 2015
Willemijn J. Jansen, MSc; Rik Ossenkoppele, PhD; Pieter Jelle Visser, MD, PhD
1Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, the Netherlands
2Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands
JAMA. 2015;314(11):1177-1178. doi:10.1001/jama.2015.9719.
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