A. W. Christopherson, M.D.
JAMA. 1933;100(25):2008. doi:10.1001/jama.1933.27420250002008a.
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I wish to report further confirmative evidence of the value of methylene blue (methylthionine chloride U. S. P.) in the treatment of carbon monoxide poisoning.

Recently five men were brought to me for emergency treatment following a "mysterious" poisoning. They had been working with a road construction crew and were blasting rock in a tunnel measuring 6 by 10 by 115 feet. The blast was set at the depth of the tunnel and ten minutes later two of the men entered the tunnel to commence work. After a few moments one of them sensed the danger and warned the other to run. The latter collapsed almost immediately and the former ran but collapsed at the mouth of the tunnel, where he was dragged to safety. One man ran into the tunnel and rescued the fallen man, but he also collapsed when safely within reach of others. These three were rushed


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