JAMA. 1926;87(13):1041. doi:10.1001/jama.1926.02680130055021.
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The development of the organs and tissues of the body is responsive to at least two quite different directive factors. One of these is the inherent or hereditary tendency to growth that determines many characteristics of the species, such as its maximal rate of gain and adult size, its form and its anatomic peculiarities. The other determinant of growth is nutritional, for obviously no organism can develop in a normal manner without food pabulum that is adequate in both kind and quantity. Underfeeding and other types of malnutrition lead to dwarfed or deformed bodies, of which numerous varieties are encountered frequently in medical practice. The newer knowledge of nutrition even supports the belief that there may be specific substances concerned primarily with the proper development of single organ systems. Thus, a directive rôle has been assigned to vitamin E in the normal functioning of the structures concerned with fertility; and


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