JAMA. 1926;87(12):943-944. doi:10.1001/jama.1926.02680120053019.
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As a result in particular of the pathologic manifestations for which it may become responsible in various ways, the gallbladder obtrudes itself frequently on the attention of the clinician. The function of this organ has remained obscure too long. The uncertainty has been accentuated by the striking circumstance that the gallbladder is always missing in certain species of the higher animals, whereas it is conspicuous as a part of the biliary tract of man. Consideration of its functions has involved questions of the storage of bile and also of the propulsion of the hepatic secretion toward the intestine. During recent years the marked concentration that the bile may undergo through sojourn in the gallbladder has become a demonstrated fact; and the knowledge of this reaction has helped to elucidate various features of pathogenic import.3 The development of cholecystography, notably by Graham and his associates4 in St. Louis, has


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