Correction: The article was corrected on December 10, 2015, to correct data in Tables.
Study concept and design: Davies, Bode, Lewin, Skjøth, Jensen.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Davies, Bode, Lewin, Skjøth, Andreasen, Jensen.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Skjøth, Andreasen, Jensen.
Study supervision: Davies, Bergenstal, Lewin, Skjøth, Jensen.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Davies reported serving on advisory boards for Novo Nordisk, Boehringer Ingelheim, Sanofi-aventis, Eli Lilly & Co, Merck Sharp & Dohme, AstraZeneca, and Janssen; acting as consultant for Novo Nordisk, Boehringer Ingelheim, Sanofi-aventis, Eli Lilly & Co, and Merck Sharp & Dohme; serving on speakers’ bureaus for Novo Nordisk, Sanofi-aventis, Eli Lilly & Co, Merck Sharp & Dohme, AstraZeneca, Janssen, Mitsubishi Tanabe Pharma Corporation, and Zealand Pharma; and receiving research support from Novo Nordisk, Novartis, Eli Lilly & Co, Merck Sharp & Dohme, Servier, GlaxoSmithKline, and Sanofi. Dr Bergenstal reported serving on advisory boards or acting as consultant for, and receiving research support from, Abbott Diabetes Care, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb/AstraZeneca, Calibra, Eli Lilly & Co, Halozyme Inc, Helmsley Trust, Hygieia, Johnson & Johnson, Medtronic, Novo Nordisk, Roche, Sanofi, and Takeda; serving on advisory boards or acting as consultant for Valeritas; and receiving research support from Becton Dickinson, Merck, ResMed, and the National Institutes of Health. Dr Bode reported acting as consultant for Novo Nordisk, Eli Lilly & Co, Sanofi, Valeritas, and Medtronic; serving on speakers’ bureaus for Novo Nordisk, Eli Lilly & Co, Sanofi, Merck, Amylin/Bristol-Myers Squibb, Valeritas, and Medtronic; serving on advisory boards for Novo Nordisk, Eli Lilly & Co, Sanofi, Valeritas, and Medtronic; and receiving research support from Novo Nordisk, Eli Lilly & Co, Sanofi, Merck, Johnson & Johnson, MannKind, Abbott, Valeritas, GlaxoSmithKline, DexCom, Pfizer, and Medtronic. Dr Kushner reported serving on advisory boards for Novo Nordisk, Vivus, Takeda, Zafgen, and Retrofit and receiving research support from Weight Watchers and Aspire Bariatrics. Dr Lewin reported receiving research support from Akros Pharma Inc, Amgen Inc, Amylin, Bavarian Nordic, Bayer Healthcare, Boehringer Ingelheim, Bristol-Myers Squibb, Catabasis, Elcelyx Therapeutics, Eli Lilly & Co, Esperion Therapeutics, Hoffmann-La Roche, Gilead Sciences, Isis Pharmaceuticals, Janssen, Merck Sharp & Dohme, Novartis, Novo Nordisk, Pfizer, Phasebio Pharmaceuticals, Pronova Biopharma, Sanofi-aventis, Theracos, and TransTech Pharma. Dr Skjøth reported holding shares in Novo Nordisk. Mr Andreasen reported providing statistical consultancy services to, and holding shares in, Novo Nordisk. Dr Jensen reported holding shares in Novo Nordisk. Dr DeFronzo reported acting as consultant for Amylin, Boehringer Ingelheim, Bristol-Myers Squibb, Janssen, Lexicon, Novo Nordisk, and Takeda; attending speakers’ bureaus for Bristol-Myers Squibb/AstraZeneca, Janssen, and Novo Nordisk; serving on advisory boards for Janssen; and receiving research support from Amylin, Boehringer Ingelheim, Bristol-Myers Squibb, Takeda, and Xeris.
NN8022-1922 Study Group:France: Paul Valensi, Marc Levy, Sonia Benabdallah, Pierre Serusclat, Jean-Pierre Courreges, Didier Gouet, Sylvaine Clavel, Bertrand Cariou; Germany: Kerstin Tyler, Markolf Hanefeld, Ralf Jordan, Karsten Milek, Ludger Rose, Joachim Sauter, Joerg Steindorf, Ulrich Wendish, Gottfried Rudofsky, Rudolf Erlinger; Israel: Ilana Harman-Boehm, Ofri Mosenzon, Josef Cohen, Avraham Karasik, Oscar Minuchin; South Africa: Hans Hendrik Snyman, Stephanus M. Komati, Puvanesveri Naiker, Johannes Jurgens Lombaard, Gracjan Podgorski, Munira Fakir Saleh; Spain: Manuel Muñoz, Luis De Teresa Parreño, Santiago Durán García, Basilio Moreno Esteban, Margarita Rivas Fernández, Angel Maria Sendón Pérez, Bartolomé Burguera, Clotilde Vázquez; Sweden: Joanna Uddén Hemmingsson, Enrique Eizyk, Aslak Rautio, Anders Norrby, Ewa Jasinska; Turkey: Abdurrahman Comlekci, Cumali Gokce, Kamile Gul; United Kingdom: Peter Mansell, Andrew B. Johnson, Ann Millward, Rudolf Bilous, David Andrew Collier, Graham Hitman, Tom Maxwell, Franklin Joseph, Mark Davis, Patrick Holmes, Sandeep Thekkepay, Adrian Park, Matt Capehorn, Shahad Taheri, Melanie Davies; United States: Vanita R. Aroda, Thomas Craig Blevins, Bruce W. Bode, Peter Bressler, Paul Ellis Bristol, Deanna Cheung, Richard M. Bergenstal, David Fitz-Patrick, Kevin Furlong, Darrell Gorman, Priscilla Hollander, David Huffman, Elise Kwon, Andrew Lewin, Robert S. Lipetz, Kathryn Jean Lucas, Jeffrey Pollock, Luis Rivera-Colon, Julio Rosenstock, Herman A. Salazar, Jean Louis Selam, John Shelmet, Henry John Simon, Norman G. Soler, Danny Sugimoto, Scott Touger, Alan Wynne, Steven B. Leichter, Eric J. Klein, Elias M. Kolettis, Lon Lynn, James T. Lane, Harold E. Bays, Ramona Granda-Rodriguez, Robert S. Busch, Kevin Cannon, Anna Chang, Christopher M. Chappel, John Timothy Dow, John Keith Earl, Victor Elinoff, Mildred V. Farmer, Joseph H. Woolley, William Stuart Gonte, Samuel Klein, Robert Kushner, Wendy S. Lane, John Albert Lang, Samuel Lerman, Barry Lubin, Paul A. Martin, Robert E. McNeill, Richard E. Mills, Alexander Vance Murray, Lyle Myers, Shichun Bao, Robert Orr, Stephanie Powell, John Chip Reed, Jackson Rhudy, William Saway, Wilson Sofley, Mark Turner, Michelle Welch, Jonathan Wilson, Tamela Sedacca Zimmerman, Ralph DeFronzo.
Funding/Support: This study was funded by Novo Nordisk. Liraglutide is a Novo Nordisk A/S proprietary compound.
Role of the Funder/Sponsor: Novo Nordisk was involved in the study design and protocol development, provided logistical support, and obtained the data, which were evaluated jointly by the authors and the sponsor. All authors interpreted the data and wrote the manuscript together with the sponsor’s medical writing services. The sponsor did not have the right to suppress or veto publications. In certain circumstances the sponsor may exercise the right to postpone publications for a short time to protect intellectual property; however, this was not the case with this publication.
Previous Presentations: American Diabetes Association (ADA) 74th Scientific Sessions; June 14, 2014; San Francisco, California. European Association for the Study of Diabetes (EASD); September 16, 2014; Vienna, Austria. ENDO 2015; March 5, 2015; San Diego, California. The Obesity Society Annual Meeting at Obesity Week 2014; November 4, 2014; Boston, Massachusetts.
Additional Contributions: We thank the study participants and the members of the NN8022-1922 study group and their staff. We also thank Niels Bindslev, MSc, and Trine Kvist, PhD, for statistical assistance as well as Frederik Flindt Kreiner, PhD, and Angela Stocks, PhD (all of Novo Nordisk A/S, Denmark), and Faye Gould, PhD (Watermeadow Medical, Witney, United Kingdom), for editorial and writing assistance. Dr Gould was compensated for her work on the manuscript.