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William Dameshek, M.D.
JAMA. 1933;100(17):1360. doi:10.1001/jama.1933.02740170058031.
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To the Editor:  —My attention has been called, particularly by Dr. Marie L. Cams of Madison, Wis., to an error in my recent article on "Primary Hypochromic Anemia," which appeared in The Journal, February 25. I implied that reduced iron was ferrous oxide (FeO) and that its actual iron content was 78 per cent. This is incorrect. Reduced iron is metallic iron which has been produced by hydrogenating ferrous oxide, the resultant material being almost pure metallic iron, containing from 90 to 100 per cent of that metal. I have used this preparation in capsules containing 1 Gm. (15 grains), the daily dosage being from 3 to 6 Gm. The actual iron content at this dosage is extremely high, from 3,000 to 6,000 mg. of iron. It is probably necessary to use this large amount of actual iron because of the insolubility of the preparation. I have not found it


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