The phenomenon of angioneurotic edema is not uncommon, but the appearance of a circumscribed edema in the same area of the body with a definite cycle warrants close investigation. Such a condition, occurring independently of the menstrual cycle and without a febrile course, relegates itself to a bizarre group of disease entities over which there is much contention regarding the proper classification.
Quincke1 in his original description of acute circumscribed edema, mentioned the tendency to recurrence in the same spots at regular intervals. Then Matas2 reported a periodic case of daily swelling of the upper lip, beginning at 8 a. m. and completely subsiding by 5 p. m. He also quoted Riehl's case with a fifteen day cycle. Osler3 mentioned the regularity of attacks, occurring in seven, twelve or fourteen day cycles. Then Collins,4 in a review of the literature, reported three cases and suggested that