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DIAGNOSTIC CRITERIA OF MALIGNANT DISEASE IN THE UPPER RIGHT QUADRANT

M. L. GRAVES, M.D.
JAMA. 1926;87(11):842-846. doi:10.1001/jama.1926.02680110042012.
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The abdomen contains no less than thirty-seven important organs and tissues, if we include the adjacent retroperitoneum, and every one of these is subject to malignant disease. The variety and complexity of these organs and resulting clinical phenomena in malignant disease are so intriguing that careful clinicians must take keen delight in every research that advances conclusive diagnosis. The upper right quadrant, the limitation of my paper, embraces no less than twelve of these organs, and is the most interesting and difficult of the abdominal divisions.

CLINICAL PHENOMENA  The number, variety and functional activities of these organs in malignant diseases will produce such alterations in the anatomy, usually progressive destruction, as may often be recognized; if physiologic alterations in secretion and excretion and absorption and motor function could be as easily recognized at early stages, much improvement in diagnosis and even in treatment would result. Subjective phenomena are still of

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