O-iodoxybenzoic acid and its precursors o-iodbenzoic acid and o-iodosobenzoic acid, were first described by Meyer and his co-workers, 1 in 1892. The action of these substances was first investigated in 1899 by Heinz, 2 who attempted to study the action of nascent iodine in the body by their use. Loevenhart and Grove 3 discussed the preparation and modification of these preparations and studied the effect of sodium iodoxybenzoate on the blood. They found only slight changes following its intravenous administration, marked by a mild polymorphonuclear leukocytosis. Grove and Loevenhart4 studied the effect of sodium iodosobenzoate and sodium iodoxybenzoate on the respiratory center and concluded that the apnea produced by these compounds was due to the presence of the oxygen combined with the iodine. They also studied the antagonism between sodium iodosobenzoate and hydrocyanic acid in regard to the respiratory center.
Arkin 5 studied the germicidal action of the compounds