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ARTICLE |

THE RESULTS OF MEDICAL TREATMENT OF PEPTIC ULCER

RALPH C. BROWN, M.D.
JAMA. 1930;95(16):1144-1148. doi:10.1001/jama.1930.02720160004002.
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Prior to 1915, when Sippy1 published his first paper on the medical treatment of ulcer, the forms of treatment in general use were chiefly of the Lenhartz type, a therapy based on bland foods, bed rest, hot fomentations and minimal doses of alkalis. Sippy became convinced that greater efficiency in treatment could be achieved by clearly recognizing the important influence of the digestive action of gastric juice on the unprotected raw surface of a gastric or duodenal ulcer. He believed that the peculiar tendency to great chronicity displayed by these lesions was due to the chemical action on the exposed surface of the ulcer of the powerful proteolytic gastric juice and advanced the theory that the healing of peptic ulcer could best be achieved by elimination of this deleterious chemical digestive action, an effect to be secured by complete neutralization of free hydrochloric acid in the gastric content from

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