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THE ORIGIN AND FATE OF UROBILIN

JAMA. 1926;87(7):492-493. doi:10.1001/jama.1926.02680070038013.
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Last year, Wallace and Diamond 1 of the New York University Medical College advocated the use of the urobilinogen test as a routine laboratory measure in all urine examinations. They believe that in icterus or latent icterus, in hepatic disorders, in the anemias, in malaria, in infections, in malignant disease and in intoxications, it will supply an important adjuvant in the routine diagnosis, and will often aid in clearing up intricate and obscure clinical conditions. It is argued that the alleged constant presence of urobilogen in catarrhal jaundice, and its total absence in mechanical icterus, such as is encountered in carcinoma of the head of the pancreas and of the biliary tract, forms a distinguishing diagnostic feature between this benign form of jaundice and those due to malignant causes. It has already been pointed out in The Journal, 2 particularly on the basis of the researches of a group of

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