The previous edition of this work was issued in 1922. In the present edition the original plan and purpose have been retained, in the main, with the addition of less than a hundred pages. Nevertheless, although the bulk is not greatly increased, the number of additions and changes is considerable. As the author points out, the original chapter on blood now comprises five chapters, and includes new material on the subjects of complement fixation, the anemias, and chemical examination of the blood. Further new features are found in the sections on urinary pigments, parasites, spinal fluid examination, cutaneous reactions, basal metabolism and liver function. Proportionally the sections on blood work take up nearly half of the book and the remainder is well apportioned to examination of the urine, the gastric and duodenal contents, the feces, the sputum and the body fluids, together with chapters on basal metabolism and bacteriologic methods.