JAMA. 1930;95(14):1022-1023. doi:10.1001/jama.1930.02720140044012.
Text Size: A A A
Published online

Hemochromatosis is a rare but readily recognized disease characterized clinically by bronzing of the skin, by ascites and other symptoms of cirrhosis of the liver, and by diabetes mellitus. Anatomically it is characterized by the widespread deposition of pigment in the tissues and organs of the body including the skin, to which the visible bronzing is due; by continuous destruction of liver cells and their replacement by connective tissue, to which the manifestations of cirrhosis are due; and by destruction of acinous and islet cells of the pancreas and their replacement by connective tissue, to which the symptoms of diabetes are due. The more exact modern knowledge of the condition dates from the classic presentation of the subject by von Recklinghausen, who in 1889 gave a thorough description of the disease and demonstrated the presence in the tissues of two kinds of pigment. One of these, which is iron-free and


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.